Journal article
Association of anal symptoms with anal high grade squamous intraepithelial lesions (HSIL) among men who have sex with men: Baseline data from the study of the prevention of anal cancer (SPANC)
SL Goddard, DJ Templeton, K Petoumenos, F Jin, RJ Hillman, C Law, JM Roberts, CK Fairley, SM Garland, AE Grulich, IM Poynten
Cancer Epidemiology | ELSEVIER SCI LTD | Published : 2019
Abstract
Background: The association between anal high-grade squamous intraepithelial lesion (HSIL) and anal symptoms has not been systematically investigated. Methods: The Study of Prevention of Anal Cancer is a prospective cohort study of men who have sex with men (MSM) ≥ 35 years old in Sydney, Australia. Self-reported symptoms were collected. Anal cytology and high-resolution anoscopy were undertaken. Using baseline visit data, men negative for squamous intra-epithelial lesion (SIL) were compared with men diagnosed with composite-HSIL (cytology and/or histology). Logistic regression analyses were performed to assess the association of symptoms with HSIL. Results: Among 414 MSM included (composite..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The SPANC study was supported by the National Health and Medical Research Council [grant number 568971]; the Cancer Council New South Wales [grant number 13-11]. Cytologic testing materials were provided by Hologic Pty Ltd. The Kirby Institute is affiliated with the Faculty of Medicine, University of New South Wales, and funded by the Australian Government of Health and Ageing.